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api 2  (Tocris)


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    Tocris api 2
    Api 2, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 53 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/api+2/API-2/pmc12789424-0-0-9
    Average 93 stars, based on 53 article reviews
    api 2 - by Bioz Stars, 2026-09
    93/100 stars

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    other:

    Article Title: Purinergic Receptor Antagonists Inhibit Hemolysis Induced by Clostridium perfringens Alpha Toxin
    Article Snippet: NF023, A438079, KN-62, MRS2211, Evans Blue, tetrasodium salt, Perifosine, API-2, PD334581, TCS ERK 11e, FR 180204, and ERK5-IN-1 were purchased from Tocris Bioscience (Abingdon, UK).

    Article Title: Compositions and methods for reactivating latent immunodeficiency virus using a GSK-3 inhibitor
    Article Snippet: Drug Treatments Anti-CD3/CD28 coated beads treatment was done at 25 μl per 1×106 cells (for bead-to-cell ratio=1:1); bryostatin-1 was used at 10 nM; panobinostat was used at 50 nM; SB-216763 (Tocris Bioscience) was used at 10/100/1000 nM; tideglusib (Selleckchem) was used at 10/100/1000 nM; SC79 (Tocris Bioscience) was used at 10/100/1000 nM; PP242 (Tocris Bioscience) was used at 250 nM; IKK-V (Millipore) was used at 25 nM, 2-DG (Sigma-Aldrich) was used at 50 mM, API-2 (Tocris Bioscience) was used at 250 nM.

    Article Title: Differential expression of phosphorylated MEK and ERK correlates with aggressive BCC subtypes.
    Article Snippet: Basal cell carcinoma (BCC) is associated with aberrant Hedgehog (HH) signalling through mutational inactivation of PTCH1; however, there is conflicting data regarding MEK/ERK signalling in BCC and the signalling pathway interactions in these carcinomas.. To address this, expression of active phospho (p) MEK and ERK were examined in a panel of 15 non-aggressive and 14 aggressive BCCs.. Although not uniformly expressed, both phospho-proteins were detected in the nuclei and/or cytoplasm of normal and tumour-associated epidermal cells however, whereas pMEK was present in all non-aggressive BCCs (14/14), pERK was rarely expressed (2/14).

    Article Title: A human iPSC-based neural spheroid platform for modelling glioblastoma infiltration using high-content imaging
    Article Snippet: API-2 , Protein kinase B (PKB/Akt) , 50 , Tocris , 2151.

    Injection:

    Article Title: AIM2 enhances Candida albicans infection through promoting macrophage apoptosis via AKT signaling.
    Article Snippet: .. Subsequently, the mice were treated with API-2 (#2151, Tocris, USA), a selective Akt inhibitor, at a dosage of 1 mg/kg/d via intraperitoneal injection for a duration of 2 days. .. The data were analyzed using GraphPad Prism software 9.4.1 (GraphPad Software, La Jolla, CA, USA).

    Article Title: AIM2 enhances Candida albicans infection through promoting macrophage apoptosis via AKT signaling
    Article Snippet: .. Subsequently, the mice were treated with API-2 (#2151, Tocris, USA), a selective Akt inhibitor, at a dosage of 1 mg/kg/d via intraperitoneal injection for a duration of 2 days. .. The data were analyzed using GraphPad Prism software 9.4.1 (GraphPad Software, La Jolla, CA, USA).



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    Image Search Results


    Red light inhibits type I collagen degradation via AKT/NRF2/HO-1 signaling pathway activation A, B: qPCR analysis of NRF2 (A) and HO-1 (B) mRNA expression in mouse skin tissue following red light treatment. n =4. C: Representative western blot assays of p-AKT, HO-1, NRF2, and type I collagen expression in aged mice treated with red light, API-2, or both. D: Western blot analysis of nuclear-cytoplasmic separation in skin tissue. Cytosolic and nuclear extracts were immunoblotted for NRF2, while GAPDH and histone H3 proteins were probed to confirm thorough separation of the cytosolic and nuclear fractions. E: Representative western blot analysis of type I collagen expression in skin tissue after red light treatment with or without HO-1i. F: Representative immunofluorescence images of type I collagen in skin sections from aged mice after 28 days of red light treatment with or without HO-1i. Scale bar: 50 μm. G: Heatmaps showing relative expression levels of DEGs involved in various MMPs. n =3. H: qPCR analysis of MMP3, MMP9, MMP12, and MMP13 mRNA expression in mouse skin tissue following red light treatment, with and without HO-1i. *** : P <0.001; **** : P <0.0001 compared to control group, and #### : P <0.0001 compared to indicated groups, one-way ANOVA for multiple groups. Data are mean±SEM.

    Journal: Zoological Research

    Article Title: Red light promotes dermis-epidermis remodeling via TGFβ and AKT-mediated collagen dynamics in naturally aging mice

    doi: 10.24272/j.issn.2095-8137.2024.405

    Figure Lengend Snippet: Red light inhibits type I collagen degradation via AKT/NRF2/HO-1 signaling pathway activation A, B: qPCR analysis of NRF2 (A) and HO-1 (B) mRNA expression in mouse skin tissue following red light treatment. n =4. C: Representative western blot assays of p-AKT, HO-1, NRF2, and type I collagen expression in aged mice treated with red light, API-2, or both. D: Western blot analysis of nuclear-cytoplasmic separation in skin tissue. Cytosolic and nuclear extracts were immunoblotted for NRF2, while GAPDH and histone H3 proteins were probed to confirm thorough separation of the cytosolic and nuclear fractions. E: Representative western blot analysis of type I collagen expression in skin tissue after red light treatment with or without HO-1i. F: Representative immunofluorescence images of type I collagen in skin sections from aged mice after 28 days of red light treatment with or without HO-1i. Scale bar: 50 μm. G: Heatmaps showing relative expression levels of DEGs involved in various MMPs. n =3. H: qPCR analysis of MMP3, MMP9, MMP12, and MMP13 mRNA expression in mouse skin tissue following red light treatment, with and without HO-1i. *** : P <0.001; **** : P <0.0001 compared to control group, and #### : P <0.0001 compared to indicated groups, one-way ANOVA for multiple groups. Data are mean±SEM.

    Article Snippet: To inhibit AKT, mice received intraperitoneal (i.p.) injections of API-2 (HY-15457, MCE, USA) at a dose of 2 mg/kg every 48 h. To inhibit TGFβ, mice received i.p. injections of SB431542 (HY-10431, MCE, USA), a TGFβR1 inhibitor, at a dose of 10 mg/kg every 48 h. To inhibit cAMP, mice received i.p. injections of SQ22536 (HY-100396, MCE, USA), an adenylate cyclase (AC) inhibitor, at a dose of 10 mg/kg every 48 h. To inhibit HO-1, mice received i.p. injections of HO-1i (HY-111798A, MCE, USA) at a dose of 1.357 mg/kg every 48 h. To inhibit intracellular free Ca 2+ , mice received i.p. injections of diltiazem (HY-B0632, MCE, USA) at a dose of 20 mg/kg every 48 h. To inhibit reactive oxygen species (ROS), mice received daily topical application of 100 mg/mL ascorbic acid (HY-B0166, MCE, USA), applied to the skin 30 min after red light exposure.

    Techniques: Activation Assay, Expressing, Western Blot, Immunofluorescence, Control